Associations between epilepsy-related polygenic risk and brain morphology in childhood

Ngo A, Liu L, Larivière S, Kebets V, Fett S, Weber CF, Royer J, Yu E, Rodríguez-Cruces R, Zhang Z, Ooi LQR, Yeo BTT, Frauscher B, Paquola C, Caligiuri ME, Gambardella A, Concha L, Keller SS, Cendes F, Yasuda CL, Bonilha L, Gleichgerrcht E, Focke NK, Kotikalapudi R, O’Brien TJ, Sinclair B, Vivash L, Desmond PM, Lui E, Vaudano AE, Meletti S, Kälviäinen R, Soltanian-Zadeh H, Winston GP, Tiwari VK, Kreilkamp BAK, Lenge M, Guerrini R, Hamandi K, Rüber T, Bauer T, Devinsky O, Striano P, Kaestner E, Hatton SN, Caciagli L, Kirschner M, Duncan JS, Thompson PM; ENIGMA Consortium Epilepsy Working Group; McDonald CR, Sisodiya SM, Bernasconi N, Bernasconi A, Gan-Or Z, Bernhardt BC. Associations between epilepsy-related polygenic risk and brain morphology in childhood. Brain. 2025. PubMed

Obesity-related brain atrophy is independent of Alzheimer’s disease protein pathways

Morys F, Liu L, Senkevich K, Gan-Or Z, Dagher A. Obesity-related brain atrophy is independent of Alzheimer’s disease protein pathways. J Alzheimers Dis. 2025. PubMed

Genetic testing for Parkinson’s disease in Israel: Insights from the Rostock Parkinson’s Disease (ROPAD) study

Anis S, Weill C, Ponger P, Nassar M, Reiner J, Chorin O, Parlar SC, Alcalay RN, Gan-Or Z, Ezra A, Saar A, Thaler A, Cohen OS, Zlotnik Y, Benizri S, Nitsan Z, Djaldetti R, Yahalom G, Schlesinger I, Klein C, Paul JJ, Curado F, Oren L, Iftikhar S, Bauer P, Gurevich T, Arkadir D, Hassin-Baer S, Greenbaum L. Genetic testing for Parkinson’s disease in Israel: Insights from the Rostock Parkinson’s Disease (ROPAD) study. Parkinsonism Relat Disord. 2025. PubMed

Genomic structural equation modeling of impulsivity and risk-taking traits reveals three latent factors distinctly associated with brain structure and development

Shishikura M, Liu L, Yu E, Zhu R, Vilar-Ribó L, Cupertino RB, Palmer AA, Sanchez-Roige S, Vainik U, Morys F, Gan-Or Z, Misic B, Dagher A. Genomic structural equation modeling of impulsivity and risk-taking traits reveals three latent factors distinctly associated with brain structure and development. Under Review. Preprint.

Coffee Consumption Is Associated With Later Age-at-Onset of Parkinson’s Disease

Kuzovenkova D, Liu L, Gan-Or Z, Senkevich K. Coffee Consumption Is Associated With Later Age-at-Onset of Parkinson’s Disease. Ann Clin Transl Neurol. 2025. PubMed

Investigating the Acute and Chronic Effects of Cardiovascular Exercise on Brain-Derived Neurotrophic Factor in Early Subacute Stroke

De Las Heras B, Rodrigues L, Cristini J, Yu E, Gan-Or Z, Arbour N, Thiel A, Tang A, Fung J, Eng JJ, Roig M. Investigating the Acute and Chronic Effects of Cardiovascular Exercise on Brain-Derived Neurotrophic Factor in Early Subacute Stroke. Neurorehabil Neural Repair. 2025. PubMed

Hereditary Spastic Paraplegia in Alberta: Lessons from a Well-Defined Cohort Including the Indigenous Population

Assaedi E, Ashtiani S, Estiar MA, Gan-Or Z, McKenzie ED, Shetty A, Rouleau G, Suchowersky O. Hereditary Spastic Paraplegia in Alberta: Lessons from a Well-Defined Cohort Including the Indigenous Population. Mov Disord Clin Pract. 2025. PubMed

Genome-wide association study of glucocerebrosidase activity modifiers.

Somerville EMKrohn LSenkevich KYu E, Ahmad JAsayesh FRuskey JA, Spiegelman D, Fahn S, Waters C, Sardi P, Alcalay RN and Gan-Or ZGenome-wide association study of glucocerebrosidase activity modifiers. Mol Neurobiol. 2025. Preprint, PubMed

LRRK2 rare-variant per-domain genetic burden in Parkinson’s Disease: association confined to the kinase domain

Parlar SC, Senkevich K, Yu E, Ruskey JA, Ahmad J, Asayesh F, Spiegelman D, Waters C, Monchi O, Dauvilliers Y, Dupré N, Greenbaum L, Hassin-Baer S, Miliukhina I, Timofeeva A, Emelyanov A, Pchelina S, Alcalay RN, Fon EA, Trempe JF, Gan-Or Z. LRRK2 rare-variant per-domain genetic burden in Parkinson’s Disease: association confined to the kinase domain. NPJ Parkinsons Dis. 2025. Pubmed

Heterozygous RAB3A variants cause cerebellar ataxia by a partial loss-of-function mechanism

Hengel H, Hannan SB, Reich S, Beijer D, Roller J, Gilsbach BK, Gloeckner CJ, Greene D, Timmann D, Depienne C, Mumford A, O’Driscoll M, Nemeth AH, Lundberg J, Rodan LH, Bruel AL, Delanne J, Deconinck T, Baets J, Gan-Or Z, Rouleau G, Suchowersky O, Estiar MA, Reich S, Toro C, Züchner S, Hazan J, Pétursson H, Harmuth F, Bauer C, Bauer P, Turro E, Lambright D, Schöls L, Synofzik M. Heterozygous RAB3A variants cause cerebellar ataxia by a partial loss-of-function mechanism. Brain. 2025. Pubmed