Digenic inheritance of mutations in SPG7 and AFG3L2 causes motor neuron and cerebellar disorders.

Estiar MAYu E, Varghaei P, Ross JP, Ashtiani S, Bayne AN, Coarelli G, Timmann D, lockgether T, Beijer D, Mengel D, Coutelier M, Project MinE ALS Sequencing Consortium, Dion PA, Suchowersky O, Ewenczyk C, Goizet C, Van Damme P, Al-Chalabi A, Zuchner S, Synofzik M, Veldink JH, Trempe JF, Durr A, Rouleau GA and Gan-Or ZDigenic inheritance of mutations in SPG7 and AFG3L2 causes motor neuron and cerebellar disorders. BMC Medicine. 2026. Preprint, PubMed

LRRK2 Kinase Mediates Increased GCase Activity in Microglia in Response to Proinflammatory Stimuli.

MacDougall EJ, Chen CXQ, Deneault E, You Z, Abdian N, Durcan TM, Senkevich K, Gan-Or Z and Fon EA. LRRK2 Kinase Mediates Increased GCase Activity in Microglia in Response to Proinflammatory Stimuli. Under review. 2026. Preprint, PubMed