Lack of Epistatic Interaction of SNCA with APOE in Synucleinopathies.

Saini P, Yu EEstiar MAKrohn L, Mufti K, Rudakou URuskey JAAsayesh F, Laurent SB, Spiegelman D, Trempe JF, Quinnell TG, Oscroft N, Arnulf I, Montplaisir JY, Gagnon JF, Desautels A, Dauvilliers Y, Gigli GL, Valente M, Janes F, Bernardini A, Sonka K, Kemlink D, Oertel W, Kaivola K, International LBD Genomics Consortium, Janzen A, Plazzi G, Antelmi E, Biscarini F, Figorilli M, Puligheddu M, Mollenhauer B, Trenkwalder C, Sixel-Doring F, Cochen De Cock V, Monaca CC, Grosset D, Heidbreder A, Ferini-Strambi L, Dijkstra F, Viaene M, Abril B, Boeve BF, Postuma RB, Rouleau GA, Anselmi V, Ibrahim A, Stefani A, Hogl B, Hu MTM, Scholz SW and Gan-Or ZLack of Epistatic Interaction of SNCA with APOE in Synucleinopathies. Under review. Preprint, PubMed

 Advancing Parkinson’s Disease Research in Canada: The Canadian Open Parkinson Network (C-OPN).

Cressatti M, Pinilla-Monsalve GD, Blais M, Normandeau CP, Degroot C, Kathol I, Borard S, Bendas A, Camicioli R, Dupré N, Gan-Or Z, Grimes DA, Kalia LV, MacDonald PA, McKeown MJ, Martino D, Miyasaki JM, Schlossmacher MG, Stoessl AJ, Strafella AP, Fon EA and Monchi O. Advancing Parkinson’s Disease Research in Canada: The Canadian Open Parkinson Network (C-OPN). Under review. Preprint, PubMed

GLON5 Frequency in idiopathic REM sleep behavior disorder: a multicenter study. 

Postuma RB, Vorasoot N, St. Louis EK, Pelletier A, Lim MM, Elliott JE, Gagnon JF, Gan-Or Z, Forsberg LK, Fields JA, Ross OA, Singer W, Huddleston DE, Bliwise DL, Avidan AY, Howell MJ, Schenck CH, McLeland J, Davis AA, Criswell SR, Videnovic A, During EH, Miglis MG, Boeve BF, Ju YES, McKeon A and the North American Prodromal Synucleinopathy (NAPS) Consortium. IGLON5 Frequency in idiopathic REM sleep behavior disorder: a multicenter studyNeurol Neuroimmunol Neuroinflamm. 2024. PubMed

Genome-wide association study of glucocerebrosidase activity modifiers.

Somerville EMKrohn LSenkevich KYu E, Ahmad JAsayesh FRuskey JA, Spiegelman D, Fahn S, Waters C, Sardi P, Alcalay RN and Gan-Or ZGenome-wide association study of glucocerebrosidase activity modifiers. Under review. Preprint, PubMed

RAB32 Ser71Arg in autosomal dominant Parkinson’s disease: linkage, association, and functional analyses.

Gustavsson EK, Follett J, Trinh J, Barodia SK, Real R, Liu Z, Grant-Peters M, Fox JD, Cresswell S, Stoessl AJ, Rajput A, Rajput AH, Auer R, Tilney R, Sturm M, Haack TB, Lesage S, Tesson C, Brice A, Vilarino-Guell C, Ryten M, Goldberg MS, West AB, Hu MT, Morris HR, Sharma M, Gan-Or Z, Samanci B, Lis P, Tocino TP, Amouri R, Ben Sassi S, Hentati F, Tonelli F, Alessi DB and Farrer MJ. RAB32 Ser71Arg in autosomal dominant Parkinson’s disease: linkage, association, and functional analyses. Lancet Neurology. 2024. PreprintPubMed

Impact of a national dementia research consortium: The Canadian Consortium on Neurodegeneration in Aging (CCNA)

Chertkow H, Phillips N, Rockwood K, Anderson N, Andrew MK, Bartha R, Beaudoin C, Bélanger N, Bellec P, Belleville S, Bergman H, Best S, Bethell J, Bherer L, Black S, Borrie M, Camicioli R, Carrier J, Cashman N, Chan S, Crowshoe L, Cuello C, Dang-Vu T, Das S, Dixon RA, Ducharme S, Einstein G,Evans AC, Fahnestock M, Feldman H, Ferland G, Finger E, Fisk J, Fogarty J, Fon E, Gan-Or Z, Gauthier S, Greenwood C, Henri-Bellemare C, Herrmann N, Hogan DB, Hsiung R, Itzhak I, Jacklin K, Lanctôt K, Lim A, MacKenzie I, Masellis M, Maxwell C, McAiney C, McGilton K, McLaurin J, Mihailidis A, Mohades Z, Montero-Odasso M, Morgan D, Naglie G, Nygaard H, O’Connell M, Pilon R, Rajah MN, Rapoport M, Roach P, Robillard JM, Rogaeva E, Rosa-Neto P, Rylett J, Sadavoy J, St. George-Hyslop P, Seitz D, Smith E, Stefanovic J, Tierney M, Vedel I, Walker JD, Wellington C, Whitehead V and Wittich W. Impact of a national dementia research consortium: The Canadian Consortium on Neurodegeneration in Aging (CCNA)J Alzheimers Dis. 2024. PubMed

Parkinson’s risk gene CTSB promotes α-synuclein clearance and lysosome function in dopamine neurons.

Jones-Tabah J, He K, Senkevich K, Karpilovsky N, Deyab G, Cousineau Y, Nikanorova D, Goldsmith T, del Cid Pellitero, Chen CXC, Luo W, You Z, Abdian N, Pietrantonio I, Goiran T, Ahmad JRuskey JAAsayesh F, Spiegelman D, Waters C, Monchi O, Dauvilliers Y, Dupré N, Miliukhina I, Timofeeva A, Emelyanov A, Pchelina S, Greenbaum L, Hassin-Baer S, Alcalay RN, Milnerwood A, Durcan TM, Gan-Or Z (co-corresponding author) and Fon EA. Parkinson’s risk gene CTSB promotes α-synuclein clearance and lysosome function in dopamine neurons. Mol Neurodegener. 2024. Preprint, PubMed

Are LRRK2 p.G2019S or GBA1 variants associated with long-term outcomes of deep brain stimulation for Parkinson’s disease?

Anis S, Goldberg T, Shvueli E, Kozlov Y, Redlich Y, Lavi N, Lavie I, Sosero YLGan-Or Z, Ungar L, Zibly Z, Greenbaum L, Fay-Karmon T and Hassin-Baer S. Are LRRK2 p.G2019S or GBA1 variants associated with long-term outcomes of deep brain stimulation for Parkinson’s disease? Parkinsonism Relat Disord. 2024. PubMed

Comorbid neurotrauma increases synucleinopathy-relevant cognitive, motor, and autonomic dysfunction in patients with REM sleep behavior disorder: A substudy of the North American Prodromal Synucleinopathy Consortium

Elliott J, Ligman B, Bryant-Ekstrand M, Keil A, Powers K, Olivio C, Neilson L, Postuma R, Pelletier A, Gagnon JF, Gan-Or ZYu ELiu L, St. Louis E, Forsberg L, Fields J, Huddleston D, Bliwise D, Avidan A, Howell M, Schenck C, McLeland J, Criswell S, Videnovic A, During E, Miglis M, Shprecher D, Lee-Iannotti J, Boeve B, Ju YE and Lim M. Comorbid neurotrauma increases synucleinopathy-relevant cognitive, motor, and autonomic dysfunction in patients with REM sleep behavior disorder: A substudy of the North American Prodromal Synucleinopathy Consortium. Sleep. 2024. PubMed

Genetics of NLRP3 suggests lack of involvement and inefficient druggability in Parkinson′s disease. 

Senkevich KLiu L, Alvarado CX, Leonard HL, Nalls MA and Gan-Or ZGenetics of NLRP3 suggests lack of involvement and inefficient druggability in Parkinson′s diseasenpj Parkinson’s disease. 2024. PreprintPubMed