Genetics of NLRP3 suggests lack of involvement and inefficient druggability in Parkinson′s disease. 

Senkevich KLiu L, Alvarado CX, Leonard HL, Nalls MA and Gan-Or ZGenetics of NLRP3 suggests lack of involvement and inefficient druggability in Parkinson′s diseasenpj Parkinson’s disease. 2024. PreprintPubMed

Dopamine pathway and Parkinson’s risk variants are associated with levodopa-induced dyskinesia.

Sosero YL, Ferwerda B, Tocino MTP, Belloso DR, Gomez-Garre P, Faouzi J, Pavelka L, Marques TM, Gomes CPC, Kolodkin A, May P, Milanowski LM, Wszolek ZK, Uitti RJ, Heutink P, van Hilten J, Simon DK, Eberly S, Fernandez IA, Krohn LYu E, Freeman K, Rudakou URuskey JAAsayesh F, Menendez M, Pastor P, Ross O, Kruger R, Corvol JC, Koks S, Mir P, de Bie RMA, Iwaki H and Gan-Or ZDopamine pathway and Parkinson’s risk variants are associated with levodopa-induced dyskinesiaMovement Disorders. 2024. PreprintPubMed

Genotype-Phenotype correlations in PRKN-associated Parkinson’s disease.

Menon PJ, Sambin S, Criniere-Boizet B, Courtin T, Tesson C, Casse F, Ferrien M, Mariani LL, Carvalho S, Lejeune FX, Rebbah S, Martet G, Houot M, Lanore A, Mangone G, Roze E, Vidailhet M, Aasly J, Gan-Or ZYu E, Dauvilliers Y, Zimprich A, Tomantschger V, Pirker W, Álvarez I, Pastor P, Di Fonzo A, Bhatia KP, Magrinelli F, Houlden H, Real R, Quattrone A, Limousin P, Korlipara P, Foltynie T, Grosset D, Williams N, Narendra D, Lin HP, Jovanovic C, Svetel M, Lynch T, Gallagher A, Vandenberghe W, Gasser T, Brockmann K, Morris HR, Borsche M, Klein C, Corti O, Brice A, Lesage S and Corvol JC. Genotype-Phenotype correlations in PRKN-associated Parkinson’s diseasenpj Parkinson’s Disease. 2024. Preprint, PubMed

Genome-wide association study stratified by MAPT haplotypes identifies potential novel loci in Parkinson’s disease

Senkevich K, Bandres-Ciga S, Cisterna-García A, Yu E, Bustos BI, Krohn L, Lubbe SJ, Botía JA, the International Parkinson’s Disease Genomics Consortium (IPDGC) and Gan-Or ZGenome-wide association study stratified by MAPT haplotypes identifies potential novel loci in Parkinson’s disease. Under review. Preprint, PubMed

APOE – e4 is not associated with pure-tone hearing thresholds, visual acuity or cognition, cross-sectionally or over 3 years of follow up in the Canadian Longitudinal Study on Aging. 

Mick P, Kabir R, Karunatilake M, Kathleen Pichora-Fuller M, Young TL, Sosero YGan-Or Z, Wittich W, Phillips NA. APOE – e4 is not associated with pure-tone hearing thresholds, visual acuity or cognition, cross-sectionally or over 3 years of follow up in the Canadian Longitudinal Study on AgingNeurobiology of Aging. 2024. PreprintPubMed

Autosomal dominant Parkinson’s disease caused by SNCA p.E46K mutation in a family with Russian ancestry.

Senkevich K, Miliukhina I, Zhuravlev A, Shumilova M, Beletskaia M, Skvortsova T, Yu EAhmad JAsayesh FGan-Or Z, Emelyanov A and Pchelina S. Autosomal dominant Parkinson’s disease caused by SNCA p.E46K mutation in a family with Russian ancestryMovement Disorders. 2024. PubMed

Neuroanatomical correlates of polygenic risk for Parkinson Disease.

Abbasi N, Tremblay C, Rajimehr R, Yu E, Markello RD, Shafiei G, Khatibi N, The ENIGMA-Parkinson’s study, Jahanshad N, Thompson PM, Gan-Or Z, Misic B and Dagher A. Neuroanatomical correlates of polygenic risk for Parkinson Disease. Under review. Preprint, PubMed

Lessons and future directions for GBA1 targeting therapies.

Gan-Or Z. Lessons and future directions for GBA1 targeting therapiesLancet Neurology. 2023. PubMed

Machine learning nominates the inositol pathway and novel genes in Parkinson’s disease.

Yu E, Larivière R, Thomas RA, Liu LSenkevich K, Rahayel S, Trempe JF, Fon EA and Gan-Or ZMachine learning nominates the inositol pathway and novel genes in Parkinson’s diseaseBrainPreprintPubMed

Epigenetic clock acceleration is linked to earlier onset and phenoconversion age in REM sleep behavior disorder.

Senkevich K, Pelletier A, Sato C, Keil A, Gan-Or Z, Lang AE, Postuma RB, and Rogaeva E. Epigenetic clock acceleration is linked to earlier onset and phenoconversion age in REM sleep behavior disorderAnnals of Neurology. 2023. PreprintPubMed