Chifamba LV, Parlar SC, Somerville EN, Liu L, Yu E, Asayesh F, Ahmad J, Teferra M, Ruskey JA, Waters C, Monchi O, Dauvilliers Y, Dupré N, Timofeeva A, Emelyanov A, Pchelina S, Miliukhina I, Greenbaum L, Hassin-Baer S, Goldstein O, Radefeldt M, Bauer P, Beetz C, Dilliott AA, Beck JC, Senkevich K; ROPAD Study Group; Parkinson’s Foundation PD GENEration Study; Klein C, Alcalay RN, Gan-Or Z. The GBA1 p.E427K (p.E388K) Variant Is a Risk Factor for Synucleinopathies: A Meta-Analysis. Mov Disord. 2026. Preprint, PubMed
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Genetic associations between post-traumatic stress disorder and REM-sleep behavior disorder
Ghamgosar Shahkhali M, Liu L, Ghamgosar Shahkhali MH, Yu E, Asayesh F, Ahmad J, Teferra M, Arnulf I, Dodet P, Ju YE, Hu MTM, Montplaisir JY, Gagnon JF, Desautels A, Ibrahim A, Stefani A, Högl B, Aktan-Süzgün M, Iranzo A, Serradell M, Montini A, Maya G, Gaig C, Gigli GL, Valente M, Janes F, Bernardini A, Dauvilliers Y, Sonka K, Kemlink D, Dusek P, Sommerauer M, Tamgüney G, Figorilli M, Puligheddu M, Cochen De Cock V, Oertel W, Janzen A, Antelmi E, Mollenhauer B, Sixel-Doring F, Terzaghi M, Fiamingo G, Skorvanek M, Kulcsarova K, Abril B, Ferini-Strambi L, Bušková J, Orso B, Mattioli P, Arnaldi D, Dijkstra F, Viaene M, Boeve BF, Ross OA, Rouleau GA, Neilson LE, Elliott JE, Lim MM, Postuma RB, Gan-Or Z. Genetic associations between post-traumatic stress disorder and REM-sleep behavior disorder. NPJ Parkinsons Dis. 2026. Preprint, PubMed.
Digenic inheritance of mutations in SPG7 and AFG3L2 causes motor neuron and cerebellar disorders.
Estiar MA, Yu E, Varghaei P, Ross JP, Ashtiani S, Bayne AN, Coarelli G, Timmann D, lockgether T, Beijer D, Mengel D, Coutelier M, Project MinE ALS Sequencing Consortium, Dion PA, Suchowersky O, Ewenczyk C, Goizet C, Van Damme P, Al-Chalabi A, Zuchner S, Synofzik M, Veldink JH, Trempe JF, Durr A, Rouleau GA and Gan-Or Z. Digenic inheritance of mutations in SPG7 and AFG3L2 causes motor neuron and cerebellar disorders. BMC Medicine. 2026. Preprint, PubMed
LRRK2 Kinase Mediates Increased GCase Activity in Microglia in Response to Proinflammatory Stimuli.
Investigating the Genetic Relationship Between Vitamin B12 Metabolism and Parkinson Disease
Dering R, Onvumere M, Liu L, Huot P, Gan-Or Z, Senkevich K. Investigating the Genetic Relationship Between Vitamin B12 Metabolism and Parkinson Disease. Neurol Genet. 2026. PubMed
Shared Pathogenic Pathways Between REM Sleep Behavior Disorder and Neurodegenerative and Psychiatric Disorders.
Zhang Z, Somerville EN, Fang ZH, Liu L, Asayesh F, Ahmad J, Amiri S, Teferra M, Dodet P, Arnulf I, Hu MTM, Desautels A, Dauvilliers Y, Aktan-Süzgün M, Ibrahim A, Stefani A, Högl B, Gaig C, Montini A, Maya G, Iranzo A, Serradell M, Gigli GL, Valente M, Janes F, Bernardini A, Sonka K, Kemlink D, Dusek P, Sommerauer M, Röttgen S, Figorilli M, Puligheddu M, Mollenhauer B, Trenkwalder C, Sixel-Doring F, Plazzi G, Biscarini F, Antelmi E, Cochen De Cock V, Terzaghi M, Fiamingo G, Heidbreder A, Ferini-Strambi L, Ostrozovicova M, Skorvanek M, Kulcsarova K, Buskova J, Abril B, Orso B, Mattioli P, Arnaldi D, Boeve BF, Ju YE, Ross OA, Wu SY, Lee J, Prilutsky D, Blauwendraat C, Leonard H, Postuma RB, Rouleau GA and Gan-Or Z. Shared Pathogenic Pathways Between REM Sleep Behavior Disorder and Neurodegenerative and Psychiatric Disorders. Under review. 2026. Preprint, PubMed
Lack of genetic evidence for a role of SLC25A46 in alpha-synucleinopathies
Yu H, Parlar SC, Senkevich K, Somerville EN, Zhang Z, Liu L, Teferra M, Ahmad J, Asayesh F, Rouleau GA and Gan-Or Z. Lack of genetic evidence for a role of SLC25A46 in alpha-synucleinopathies. Under review. 2026. Preprint, PubMed
Machine learning and burden analyses highlight novel genes in Parkinson’s Disease.
Parlar SC, Yu E, Kanagasingam S, Zhang Z, Liu L, Ghamgosar Shahkhali M, Chantereault C, Karpilovsky N, Worrall D, Thomas RA, Senkevich K, Fon EA and Gan-Or Z. Machine learning and burden analyses highlight novel genes in Parkinson’s Disease. Under review. 2026. Preprint, PubMed
Somerville EN, Liu L, Ta M, Iwaki H, Senkevich K, Alcalay RN and Gan-Or Z. Genome-wide association studies identify genetic determinants of synucleinopathy biomarkers. Under review. 2026. Preprint, PubMed
Brain size links neurodevelopment to neurodegeneration in Parkinson’s disease.
Azizi H, Abbasi N, Liu L, Pastor-Bernier A, Tremblay C, Pourmajidian M, Senkevich K, Morys F, Vo A, Moqadam R, Rajimehr R, Yu E, Savadjiev P, Markello RD, Shafiei G, Khatibi N, Jahanshad N, Thompson PM, Poline JB, Gan-Or Z, Misic B, Zeighami Y and Dagher A. Brain size links neurodevelopment to neurodegeneration in Parkinson’s disease. Under review. 2026. Preprint, PubMed