Genome-wide association study stratified by MAPT haplotypes identifies potential novel loci in Parkinson’s disease

Senkevich K, Bandres-Ciga S, Cisterna-García A, Yu E, Bustos BI, Krohn L, Lubbe SJ, Botía JA, the International Parkinson’s Disease Genomics Consortium (IPDGC) and Gan-Or ZGenome-wide association study stratified by MAPT haplotypes identifies potential novel loci in Parkinson’s disease. Under review. Preprint, PubMed

APOE – e4 is not associated with pure-tone hearing thresholds, visual acuity or cognition, cross-sectionally or over 3 years of follow up in the Canadian Longitudinal Study on Aging. 

Mick P, Kabir R, Karunatilake M, Kathleen Pichora-Fuller M, Young TL, Sosero YGan-Or Z, Wittich W, Phillips NA. APOE – e4 is not associated with pure-tone hearing thresholds, visual acuity or cognition, cross-sectionally or over 3 years of follow up in the Canadian Longitudinal Study on AgingNeurobiology of Aging. 2024. PreprintPubMed

Autosomal dominant Parkinson’s disease caused by SNCA p.E46K mutation in a family with Russian ancestry.

Senkevich K, Miliukhina I, Zhuravlev A, Shumilova M, Beletskaia M, Skvortsova T, Yu EAhmad JAsayesh FGan-Or Z, Emelyanov A and Pchelina S. Autosomal dominant Parkinson’s disease caused by SNCA p.E46K mutation in a family with Russian ancestryMovement Disorders. 2024. PubMed

Neuroanatomical correlates of polygenic risk for Parkinson Disease.

Abbasi N, Tremblay C, Rajimehr R, Yu E, Markello RD, Shafiei G, Khatibi N, The ENIGMA-Parkinson’s study, Jahanshad N, Thompson PM, Gan-Or Z, Misic B and Dagher A. Neuroanatomical correlates of polygenic risk for Parkinson Disease. Under review. Preprint, PubMed

Lessons and future directions for GBA1 targeting therapies.

Gan-Or Z. Lessons and future directions for GBA1 targeting therapiesLancet Neurology. 2023. PubMed

Machine learning nominates the inositol pathway and novel genes in Parkinson’s disease.

Yu E, Larivière R, Thomas RA, Liu LSenkevich K, Rahayel S, Trempe JF, Fon EA and Gan-Or ZMachine learning nominates the inositol pathway and novel genes in Parkinson’s diseaseBrainPreprintPubMed

Epigenetic clock acceleration is linked to earlier onset and phenoconversion age in REM sleep behavior disorder.

Senkevich K, Pelletier A, Sato C, Keil A, Gan-Or Z, Lang AE, Postuma RB, and Rogaeva E. Epigenetic clock acceleration is linked to earlier onset and phenoconversion age in REM sleep behavior disorderAnnals of Neurology. 2023. PreprintPubMed

MerTK is a mediator of alpha-synuclein fibril uptake by human microglia

Dorion MF, Yaqubi M, Senkevich K, Kieran NW, MacDonald A, Chen CXQ, Luo W, Wallis A, Shlaifer I, Hall JA, Dudley RWR, Glass IA; Birth Defects Research Laboratory; Stratton JA, Fon EA, Bartels T, Antel JP, Gan-Or Z, Durcan TM, Healy LM. MerTK is a mediator of alpha-synuclein fibril uptake by human microglia. Brain. 2024. PreprintPubMed

Association of rare variants in ARSA with Parkinson’s disease.

Senkevich K, Beletskaia M, Dworkind AYu EAhmad JRuskey JAAsayesh F, Spiegelman D, Fahn S, Waters C, Monchi O, Dauvilliers Y, Dupré N, Greenbaum L, Hassin-Baer S, Nagornov I, Tyurin A, Miliukhina I, Timofeeva A, Emelyanov A, Zakharova E, Alcalay RN, Pchelina A and Gan-Or ZAssociation of rare variants in ARSA with Parkinson’s diseaseMovement Disorder. 2023. Preprint, PubMed

HLA in isolated REM sleep behavior disorder and Lewy body dementia.

Yu EKrohn LRuskey JAAsayesh F, Spiegelman D, Shah Z, Chia R, Arnulf I, Hu MTM, Montplaisir JY, Gagnon JF, Desautels A, Dauvilliers Y, Gigli GL, Valente M, Janes F, Bernardini A, Hogl B, Stefani A, Ibrahim A, Heidbreder A, Sonka K, Dusek P, Kemlink D, Oertel W, Janzen A, Plazzi G, Antelmi E, Figorilli M, Puligheddu M, Mollenhauer B, Trenkwalder C, Sixel-Doring F, Cochen De Cock V, Ferini-Strambi L, Dijkstra F, Viaene M, Abril B, Boeve BF, Rouleau GA, Postuma RB, The International LBD Genomics Consortium, Scholz SW and Gan-Or ZHLA in isolated REM sleep behavior disorder and Lewy body dementiaAnnals of Clinical and Translational Neurology. 2023. PreprintPubMed