Brain size links neurodevelopment to neurodegeneration in Parkinson’s disease.

Azizi H, Abbasi N, Liu L, Pastor-Bernier A, Tremblay C, Pourmajidian M, Senkevich K, Morys F, Vo A, Moqadam R, Rajimehr R, Yu E, Savadjiev P, Markello RD, Shafiei G, Khatibi N, Jahanshad N, Thompson PM, Poline JB, Gan-Or Z, Misic B, Zeighami Y and Dagher A. Brain size links neurodevelopment to neurodegeneration in Parkinson’s disease. Under review. 2026. Preprint, PubMed

Genome-wide association study of REM-sleep behaviour disorder identifies new risk loci

Somerville EN, Liu L, Krohn L, Asayesh F, Ahmad J, Spiegelman D, Teferra M, Tan M, Waters S, Simonet C, Pérez-Carbonell L, Schrag A, Dodet P, Arnulf I, Hu MTM, Ju YE, Montplaisir JY, Gagnon JF, Desautels A, Dauvilliers Y, Aktan-Süzgün M, Ibrahim A, Stefani A, Hogl B, Gaig C, Montini A, Maya G, Iranzo A, Serradell M, Gigli GL, Valente M, Janes F, Bernardini A, Sonka K, Kemlink D, Dusek P, Tamgüney G, Sommerauer M, FigorilliM, Puligheddu M, Mollenhauer B, Trenkwalder C, Sixel-Doring F, Plazzi G, Biscarini F, Antelmi E, Cochen De Cock V, Oertel W, Janzen A, Terzaghi M, Fiamingo G, Heidbreder A, Monaca CC, Ferini-Strambi L, Kulsarova K, Ostrozovicova M, Skorvanek M, Dijkstra F, Viaene M, Bušková J, Abril B, Orso B, Mattioli P, Arnaldi D, Boeve BF, Rouleau GA, Postuma RB, Chung J, Prilutsky D, Atterling Brolin K, Noyce AJ, Ross OA, Blauwendraat C and Gan-Or Z. Genome-wide association study of REM-sleep behaviour disorder identifies new risk loci. Under review. 2026. Preprint, Pubmed

Genomic structural equation modeling of impulsivity and risk-taking traits reveals three latent factors distinctly associated with brain structure and development

Shishikura M, Liu L, Yu E, Zhu R, Vilar-Ribó L, Cupertino RB, Palmer AA, Sanchez-Roige S, Vainik U, Morys F, Gan-Or Z, Misic B, Dagher A. Genomic structural equation modeling of impulsivity and risk-taking traits reveals three latent factors distinctly associated with brain structure and development. Under Review. 2026. Preprint, PubMed.

Polygenic scores for disease risk are not associated with clinical outcomes in Parkinson’s disease.

Tan MMX, Iwaki H, Bandres-Ciga S, Sosero Y, Shoai M, Brockmann K, Williams NM, Alcalay RN, Maple-Grødem J, Alves G, Tysnes OB, Auinger P, Eberly S, Heutink P, Simon DK, Kieburtz K, Hardy J, Williams-Gray CH, Grosset DG, Corvol JC, Gan-Or Z, Toft M and Pihlstrøm L. Polygenic scores for disease risk are not associated with clinical outcomes in Parkinson’s disease. Under review. 2026. Preprint, PubMed

Neuroanatomical correlates of polygenic risk for Parkinson Disease.

Abbasi N, Tremblay C, Rajimehr R, Yu E, Markello RD, Shafiei G, Khatibi N, The ENIGMA-Parkinson’s study, Jahanshad N, Thompson PM, Gan-Or Z, Misic B and Dagher A. Neuroanatomical correlates of polygenic risk for Parkinson Disease. Under review. 2026. Preprint, PubMed

Loss-of-Function Variants in CPT1C: No Support for a Causal Role in Hereditary Spastic Paraplegia

Zhu R, Liu L, Estiar MA, Asayesh F, Ahmad J, Teferra M, Yoon G, Tarnopolsky M, Boycott KM, Dupre N, Dion PA, Suchowersky O, Jordanova A, Lee YC, Stevanin G, Zuchner S, Rouleau GA, Gan-Or Z. Loss-of-Function Variants in CPT1C: No Support for a Causal Role in Hereditary Spastic Paraplegia. Mov Disord. 2025. Preprint, PubMed.

Lack of Association Between G6PD Variants and Parkinson’s Disease

Chifamba LV, Parlar SC, Liu L, Sokol LL, Yu E, Asayesh F, Ahmad J, Ruskey JA, Spiegelman D, Waters C, Monchi O, Dauvilliers Y, Dupré N, Timofeeva A, Emelyanov A, Pchelina S, Miliukhina I, Greenbaum L, Hassin-Baer S, Alcalay RN, Espay AJ, Gan-Or Z, Senkevich K. Lack of Association Between G6PD Variants and Parkinson’s Disease. HGG Adv. 2025. Preprint, PubMed.

No Evidence for Genetic Role of the Tumor Necrosis Factor Pathway in Parkinson’s Disease.

Shahkhali MG, Liu L, Somerville EN, Noyce AJ, Gan-Or Z, Senkevich K. No Evidence for Genetic Role of the Tumor Necrosis Factor Pathway in Parkinson’s Disease. NPJ Parkinsons Dis. 2025. Preprint, PubMed.

Lack of epistatic interaction of SNCA with APOE in synucleinopathies

Saini P, Yu E, Estiar MA, Krohn L, Mufti K, Rudakou U, Ruskey JA, Asayesh F, Laurent SB, Spiegelman D, Arnulf I, Montplaisir JY, Gagnon JF, Desautels A, Dauvilliers Y, Gigli GL, Valente M, Janes F, Bernardini A, Šonka K, Kemlink D, Oertel WH, Kaivola K, Janzen A, Plazzi G, Antelmi E, Biscarini F, Figorilli M, Puligheddu M, Mollenhauer B, Trenkwalder C, Sixel-Döring F, Cochen De Cock V, Monaca CC, Heidbreder A, Ferini-Strambi L, Dijkstra F, Viaene M, Abril B, Boeve BF, Postuma RB, Rouleau GA, Anselmi V, Ibrahim A, Stefani A, Högl B, Hu MTM, Scholz SW, Gan-Or Z. Lack of epistatic interaction of SNCA with APOE in synucleinopathies. Brain Commun. 2025. Preprint, PubMed

GBA1 Variants with Unknown Classification Are Modest Contributors to Parkinson’s Disease Susceptibility

Parlar SC, Lee Y, Gan-Or Z. GBA1 Variants with Unknown Classification Are Modest Contributors to Parkinson’s Disease Susceptibility. Mov Disord. 2025. Preprint, PubMed.