Blog

The Quebec Parkinson Network: A researcher-patient matching platform and multimodal biorepository.

Gan-Or Z, Rao T, Leveille E, Degroot C, Chouinard S, Cicchetti F, Dagher A, Das S, Desautels A, Drouin-Ouellet J, Durcan T, Gagnon JF, Genge A, Karamchandani J, Lafontaine AL, Lai Wing Sun S, Langlois M, Levesque M, Melmed C, Panisset M, Parent M, Poline JB, Postuma RB, Pourcher E, Rouleau GA, Sharp M, Monchi O, Dupré N and Fon EA. The Quebec Parkinson Network: A researcher-patient matching platform and multimodal biorepository. Journal of Parkinson’s Disease. 2020. PubMed

Genetic, structural and functional evidence link TMEM175 to synucleinopathies.

Krohn L, Öztürk TN, Vanderperre B, Ouled Amar Bencheikh B, Ruskey JA, Laurent SB, Spiegelman D, Postuma RB, Arnulf I, Hu MTM, Dauvilliers Y, Högl B, Stefani A, Monaca CC, Plazzi G, Antelmi E, Ferini-Strambi L, Heidbreder A, Rudakou U, Cochen De Cock V, Young P, Wolf P, Oliva P, Zhang XK, Greenbaum L, Liong C, Gagnon JF, Desautels A, Hassin-Baer S, Montplaisir JY, Dupré N, Rouleau GA, Fon EA, Trempe JF, Lamoureux G, Alcalay RN and Gan-Or ZGenetic, structural and functional evidence link TMEM175 to synucleinopathiesAnnals of Neurology. 2020. PubMed

Genetic modifiers of risk and age at onset in GBA associated Parkinson’s disease and Lewy body dementia.

Blauwendraat C, Reed X, Krohn L, Heilborn K, Bandres-Ciga S, Tan M, Gibbs R, Hernandez DG, Kumaran R, Langston R, Bonet-Ponce L, Alcalay RN, Hassin-Baer S, Greenbaum L, Iwaki H, Leonard H, Grenn FP, Ruskey JA, Sabir M, Ahmed S, Makarious MB, Pihlstrøm L, Toft M, van Hilten JJ, Marinus J, Schulte C, Brockmann K, Sharma M, Siitonen A, Majamaa K, Eerola-Rautio J, Tienari PJ, Pantelyat A, Hillis-Trupe AE, Dawson TM, Rosenthal LS, Albert MS, Resnick SM, Ferrucci L, Morris CM, Pletnikova O, Troncoso J, Grosset D, Lesage S, Corvol JC, Brice A, Noyce AJ, Masliah E, Wood N, Hardy J, Shulman LM, Jankovic J, Shulman JM, Heutink P, Gasser T, Cannon P, Scholz SW, Morris H, Cookson M, Nalls MA, Gan-Or Z* and Singleton A* (*equal contribution). Genetic modifiers of risk and age at onset in GBA associated Parkinson’s disease and Lewy body dementia. Brain. 2020. PubMedPreprint

Analysis of common and rare VPS13C variants in late onset Parkinson disease.

Rudakou URuskey JAKrohn L, Laurent SB, Spiegelman D, Greenbaum L, Yahalom G, Desautels A,  Montplaisir JY, Fahn S, Waters CH, Levy O, Kehoe CM, Narayan S, Dauvilliers Y, Dupré N, Hassin-Baer S, Alcalay RN, Rouleau GA, Fon EA and Gan-Or ZAnalysis of common and rare VPS13C variants in late onset Parkinson disease. Neurology Genetics.  2020. PubMedPreprint

Age at Onset of Parkinson’s Disease Among Ashkenazi Jewish Patients: Contribution of Environmental Factors, LRRK2 p.G2019S and GBA p.N370S Mutations.

Yahalom G, Rigbi A, Israeli-Korn S, Krohn LRudakou URuskey JA, Benshimol L, Tsafnat T, Gan-Or Z, Hassin-Baer S and Greenbaum L. Age at Onset of Parkinson’s Disease Among Ashkenazi Jewish Patients: Contribution of Environmental Factors, LRRK2 p.G2019S and GBA p.N370S MutationsJournal of Parkinson’s Disease. 2020. PubMed

Variants in the Niemann-Pick type C gene NPC1 are not associated with Parkinson’s disease. 

Ouled Amar Bencheikh BSenkevich KRudakou UYu EMufti KRuskey JAAsayesh F, Laurent SB, Spiegelman D, Fahn S, Waters C, Monchi O, Dauvilliers Y, Espay AJ, Dupré N, Greenbaum L, Hassin-Baer S, Rouleau GA, Alcalay RN, Fon EA and Gan-Or Z. Variants in the Niemann-Pick type C gene NPC1 are not associated with Parkinson’s disease. Neurobiology of Aging. 2020. PubMedPreprint

Lysosomal dysfunction in Parkinson’s disease; evidence from human genetics.

Senkevich K and Gan-Or ZLysosomal dysfunction in Parkinson’s disease; evidence from human genetics. Parkinsonism and Related Disorders. 2019. Review. PubMed

No evidence for a role of variation in alcohol dehydrogenase genes in the risk for Parkinson’s disease

Kim JJ, Bandres-Ciga S, Blauwendraat C, International Parkinson’s Disease Genomics Consortium and Gan-Or ZNo evidence for a role of variation in alcohol dehydrogenase genes in the risk for Parkinson’s disease. Neurobiology of Aging. 2019. PubMedPreprint

Genetic and epidemiological characterization of restless legs syndrome in Québec.

Akçimen F, Ross JP, Sarayloo F, Liao C, Oliveira RDB, Ruskey JA, Bourassa CV, Xiong L, Dion PA, Gan-Or Z and Rouleau GA. Genetic and epidemiological characterization of restless legs syndrome in Québec. Sleep. 2019. PubMed

Makarious MB, Diez-Fairen M, Krohn L, Kia D, Blauwendraat C, Bandres-Ciga S, Ding J, Pihlstrom L, Houlden H, Scholz SW and Gan-Or ZARSA variants in a-synucleinopathies. Brain. 2019. PubMed