Parkinson’s risk gene CTSB promotes α-synuclein clearance and lysosome function in dopamine neurons.

Jones-Tabah J, He K, Senkevich K, Karpilovsky N, Deyab G, Cousineau Y, Nikanorova D, Goldsmith T, del Cid Pellitero, Chen CXC, Luo W, You Z, Abdian N, Pietrantonio I, Goiran T, Ahmad JRuskey JAAsayesh F, Spiegelman D, Waters C, Monchi O, Dauvilliers Y, Dupré N, Miliukhina I, Timofeeva A, Emelyanov A, Pchelina S, Greenbaum L, Hassin-Baer S, Alcalay RN, Milnerwood A, Durcan TM, Gan-Or Z (co-corresponding author) and Fon EA. Parkinson’s risk gene CTSB promotes α-synuclein clearance and lysosome function in dopamine neurons. Mol Neurodegener. 2024. Preprint, PubMed

Parkinson’s risk gene CTSB promotes α-synuclein clearance and lysosome function in dopamine neurons. Under review. 2023

Jones-Tabah J, He K, Senkevich K, Karpilovsky N, Deyab G, Cousineau Y, Nikanorova D, Goldsmith T, del Cid Pellitero, Chen CXC, Luo W, You Z, Abdian N, Pietrantonio I, Goiran T, Ahmad JRuskey JAAsayesh F, Spiegelman D, Waters C, Monchi O, Dauvilliers Y, Dupré N, Miliukhina I, Timofeeva A, Emelyanov A, Pchelina S, Greenbaum L, Hassin-Baer S, Alcalay RN, Milnerwood A, Durcan TM, Gan-Or Z (co-corresponding author) and Fon EA. Parkinson’s risk gene CTSB promotes α-synuclein clearance and lysosome function in dopamine neurons. Under review. 2023. Preprint, PubMed

Are LRRK2 p.G2019S or GBA1 variants associated with long-term outcomes of deep brain stimulation for Parkinson’s disease?

Anis S, Goldberg T, Shvueli E, Kozlov Y, Redlich Y, Lavi N, Lavie I, Sosero YLGan-Or Z, Ungar L, Zibly Z, Greenbaum L, Fay-Karmon T and Hassin-Baer S. Are LRRK2 p.G2019S or GBA1 variants associated with long-term outcomes of deep brain stimulation for Parkinson’s disease? Parkinsonism Relat Disord. 2024. PubMed

Comorbid neurotrauma increases synucleinopathy-relevant cognitive, motor, and autonomic dysfunction in patients with REM sleep behavior disorder: A substudy of the North American Prodromal Synucleinopathy Consortium

Elliott J, Ligman B, Bryant-Ekstrand M, Keil A, Powers K, Olivio C, Neilson L, Postuma R, Pelletier A, Gagnon JF, Gan-Or ZYu ELiu L, St. Louis E, Forsberg L, Fields J, Huddleston D, Bliwise D, Avidan A, Howell M, Schenck C, McLeland J, Criswell S, Videnovic A, During E, Miglis M, Shprecher D, Lee-Iannotti J, Boeve B, Ju YE and Lim M. Comorbid neurotrauma increases synucleinopathy-relevant cognitive, motor, and autonomic dysfunction in patients with REM sleep behavior disorder: A substudy of the North American Prodromal Synucleinopathy Consortium. Sleep. 2024. PubMed

Comorbid neurotrauma increases synucleinopathy-relevant cognitive, motor, and autonomic dysfunction in patients with REM sleep behavior disorder: A substudy of the North American Prodromal Synucleinopathy Consortium.

Elliott J, Ligman B, Bryant-Ekstrand M, Keil A, Powers K, Olivio C, Neilson L, Postuma R, Pelletier A, Gagnon JF, Gan-Or ZYu ELiu L, St. Louis E, Forsberg L, Fields J, Huddleston D, Bliwise D, Avidan A, Howell M, Schenck C, McLeland J, Criswell S, Videnovic A, During E, Miglis M, Shprecher D, Lee-Iannotti J, Boeve B, Ju YE and Lim M. Comorbid neurotrauma increases synucleinopathy-relevant cognitive, motor, and autonomic dysfunction in patients with REM sleep behavior disorder: A substudy of the North American Prodromal Synucleinopathy Consortium. Sleep. 2024. PubMed

Genetics of NLRP3 suggests lack of involvement and inefficient druggability in Parkinson′s disease. 

Senkevich KLiu L, Alvarado CX, Leonard HL, Nalls MA and Gan-Or ZGenetics of NLRP3 suggests lack of involvement and inefficient druggability in Parkinson′s diseasenpj Parkinson’s disease. 2024. PreprintPubMed

Dopamine pathway and Parkinson’s risk variants are associated with levodopa-induced dyskinesia.

Sosero YL, Ferwerda B, Tocino MTP, Belloso DR, Gomez-Garre P, Faouzi J, Pavelka L, Marques TM, Gomes CPC, Kolodkin A, May P, Milanowski LM, Wszolek ZK, Uitti RJ, Heutink P, van Hilten J, Simon DK, Eberly S, Fernandez IA, Krohn LYu E, Freeman K, Rudakou URuskey JAAsayesh F, Menendez M, Pastor P, Ross O, Kruger R, Corvol JC, Koks S, Mir P, de Bie RMA, Iwaki H and Gan-Or ZDopamine pathway and Parkinson’s risk variants are associated with levodopa-induced dyskinesiaMovement Disorders. 2024. PreprintPubMed

Genotype-Phenotype correlations in PRKN-associated Parkinson’s disease.

Menon PJ, Sambin S, Criniere-Boizet B, Courtin T, Tesson C, Casse F, Ferrien M, Mariani LL, Carvalho S, Lejeune FX, Rebbah S, Martet G, Houot M, Lanore A, Mangone G, Roze E, Vidailhet M, Aasly J, Gan-Or ZYu E, Dauvilliers Y, Zimprich A, Tomantschger V, Pirker W, Álvarez I, Pastor P, Di Fonzo A, Bhatia KP, Magrinelli F, Houlden H, Real R, Quattrone A, Limousin P, Korlipara P, Foltynie T, Grosset D, Williams N, Narendra D, Lin HP, Jovanovic C, Svetel M, Lynch T, Gallagher A, Vandenberghe W, Gasser T, Brockmann K, Morris HR, Borsche M, Klein C, Corti O, Brice A, Lesage S and Corvol JC. Genotype-Phenotype correlations in PRKN-associated Parkinson’s diseasenpj Parkinson’s Disease. 2024. Preprint, PubMed

Genome-wide association study of REM sleep behavior disorder in Parkinson’s disease.

Sosero YL, Heilbron K, Fontanillas P, Norcliffe-Kaufmann L, Yu ERudakou URuskey JA, Freeman K, Asayesh F, Brolin K, Swanberg M, Morris HR, Wu L, Real R, Pihlstrøm L, Tan M, Gasser T, Brockmann K, Liu H, Hu MTM, Grosset DG, Lewis SJG, Kwok JB, Pastor P, Alvarez I, Skorvanek M, Lackova A, Ostrozovicova M, Rizig M, 23andMe Research Team, The International Parkinson’s Disease Genomics Consortium, Krohn L and Gan-Or ZGenome-wide association study of REM sleep behavior disorder in Parkinson’s disease. Under review. 2024. Preprint, PubMed

Genome-wide association study stratified by MAPT haplotypes identifies potential novel loci in Parkinson’s disease

Senkevich K, Bandres-Ciga S, Cisterna-García A, Yu E, Bustos BI, Krohn L, Lubbe SJ, Botía JA, the International Parkinson’s Disease Genomics Consortium (IPDGC) and Gan-Or ZGenome-wide association study stratified by MAPT haplotypes identifies potential novel loci in Parkinson’s disease. Under review. Preprint, PubMed